Abstract: Infertility is one of the most tragic of all marital problems. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The infertility may be due to an inadequate number of spermatozoa in the semen, the failure of the spermatozoa to move with sufficient vigor towards their goal or that they are deficient in other respects. Aims of the study is to investigate the safety and efficacy of Xperm (Herbal Medicine) in test group in comparison with Sulfonylureas plus (Allopathic) in control group. A Causi experimental randomized controlled, two-arm parallel group clinical trial conducted at Shifa-ul-Mulk Memorial Hospital for Eastern Medicine, Hamdard University Karachi. Hundred patients in the age group of 20-50 years with idiopathic infertility with a total sperm count less than 20 million/ml. Comparison of data recorded by participants relating to these variables showed significant differences between test and control groups (p<0.05) despite the fact that no side effects were at all recorded in test group. Overall clinical success was observed in both treatment groups however the efficacy of the test treated medication (Xperm) was superior as p = 0.03. Xperm is more effective than the Sulfonylureas plus in the treatment of Oligospermia and male infertility.