Abstract: The effect of Acalypha wilkesiana leaves on plasma levels of sodium and potassium were studied in normal rabbits given daily, by intra-gastric gavage, 1g/kg of the leaf, in the form of decoction prepared by mixing 5g of air-dried powdered leaves in 10 mL water. The treatment led to significant decreases (p<0.05) in plasma sodium concentrations and significant increases in potassium concentrations. These findings connote a therapeutic advantage in the use of A. wilkesiana for the treatment of hypertension, especially in managing the abnormal sodium and potassium metabolisms that accompany hypertension.