Abstract: The effects of dietary palm and corn oil levels on plasma lipoprotein profile were investigated in albino rats Four week-old Wistar rats (n=8 per group) were maintained (for 28 days) on standard rat food supplemented (10, 20 and 30% by weight) with red palm oil (RPO), refined palm olein (REFPO) and corn oil (CO). Rats fed the experimental diets exhibited a direct dose-effect relationship between levels of dietary fat and total cholesterol (TC) concentrations. At each level of dietary intake, the cholesterolemia effects of corn oil-based diets were less than those of palm oil (red or refined), while the cholesterolemia effects of REFPO-based diets were intermediate between those of RPO and CO-based diets. The groups fed 30% oil supplemented diets had significantly lower (P<0.05) high density lipoprotein cholesterol [HDL-C]: TC ratios (0.45-0.49) than other experimental groups studied (0.60-0.69). The plasma non-HDL-cholesterol concentrations of the animals fed 30% oil-containing diets (1.38-1.54mmol/L) were higher than in other experimental groups (0.89-1.54mmol/L). The above findings demonstrate that cholesterol status is influenced by changes in concentration of dietary fat. Consumption of high levels of fat may be a risk factor for cardiovascular disease by raising plasma non-HDL-C concentrations and lowering plasma HDL-C concentrations.