Abstract: Background and Objectives: Salvia officinalis (Sage) is a plant native to the Middle East and Mediterranean areas. It is from the family of Labiatae used for the treatment of different kinds of disorders. In the present study, ethanolic extracts of Salvia officinalis screened for its chemical composition. Materials and Methods: The extract obtained from Silvia officinalis growing wild in Al-Karak, Jordan, investigated for its photo components for the first time. The extract analyzed by GC-MS and HPLC instruments. The aerial part of the plant collected at the beginning of spring 2018. Results: Results show that the ethanolic extract has 28 natural compounds with 95.30% of the total identified components. Two peaks with 4.70% of total composition could not be identified. This analysis revealed that the compounds are mainly composed of aromatics and oxygenated hydrocarbons. Such as; L-Ascorbic acid, Silane, D-Glucuronic acid, Phenobarbital and Undecanedioic acid. Conclusion: Overall this study highlights the identification of several oxygenated hydrocarbons of phytochemical compounds with two unknown components. Further investigation is needed for structural elucidation directed with pharmacological activity.