Abstract: Background and Objective: Seed-dressing or coating substances play a role to control underground pests, having ability to kill seed and seedling diseases, promote seedling healthy growth, improve the crop quality and seed germination rate. Materials and Methods: This investigation was carried out in order to study protein banding pattern, antioxidant enzymes activity, leaves ultrastructure in maize and wheat coating with fungicides, hattrick (6%) and premis (25%), respectively during three vegetation stages. Results: The protein profile of maize and wheat showed the appearance of 6, 4, 23 and 21 monomorphic bands at the 2nd and 3rd stage, respectively. Catalase and peroxidase activities of treated plants were increased. In ultrastructure measurement treatment caused decrease or increase in the measured parameters, with appearance of starch grains in treated maize and disappearance in treated wheat. The soil properties and soil microflora showed marked differences in response to the used treatments. Conclusion: From results we can concluded that dressing maize and wheat grains with the prospective dose of hattrick and premis, respectively enhance growth and the response was more pronounced in maize plants.