Abstract: Background and Objective: Type II Diabetes (T2D) is considered a major health burden locally, regionally and internationally. Gender differences in T2D prevalence were found in several epidemiological and observational studies. The primary goal of this study was to assess the prevalence of T2D-related comorbidities and treatment modalities and the impact of gender. Materials and Methods: This was a cross-sectional study that was conducted between June of 2013 and July of 2016 for patients with T2D at the 2 main outpatient diabetes clinics in Taif city, Saudi Arabia. Those with type I diabetes, gestational diabetes and drug-induced diabetes were excluded. Result: A total of 945 patients with a mean age of 58.4±11.8 years with a nearly equal distribution among both genders but with slightly more male predominance (52.2%). When compared to females, male patients were more likely to be older (p<0.001) and exhibit a longer T2D duration (P 0.003), lower mean BMI (p<0.001), lower systolic blood pressure (P 0.062), higher diastolic blood pressure (P 0.468), less likely to have hypertension and be on ACE/ARB blockers (P 0.065 and 0.019, respectively), more likely to have hyperlipidemia and be on a statin (P 0.065 and 0.124, respectively), and more likely to have cardiac disease and stroke and to be on beta-blockers (P 0.005, 0.279, 0.005, respectively). Conclusion: Both genders exhibited comparable HbA1c levels. Medical treatment optimization along with controlling both measured cardiovascular makers and laboratory result levels was based on comorbidities and complications rather than gender.