Abstract: Background and Objective: Using the foliar application in development agriculture became a new strategy in the production system to decrease the cost of nutrition. This study amid to investigate the effect of yeast and algae on yield and quality of soybean under fertigation in newly soils at Wadi El-Natroun, El-Behaira Governorate, Egypt, during the two seasons 2018 and 2019. Materials and Methods: The experimental design was a split-plot design in a randomized complete block arrangement with three replications. Yeast and algae were allocated to the main plots, while rates treatments were distributed at random in the sub-plots and control treatment foliar water. Results: The results showed that either the foliar application with algae and yeast stimulates many growth aspects individually, such as plant length, number of seeds/plant and seed weight/plant compared to the control treatment. In addition, foliar spraying with algae at 8 g L–1 increased NPK content, crude protein content and total carbohydrate in seed. Conclusion: This study concluded that the foliar application influences at algae have provided high yields and chemical constituents under fertigation in sandy soil.