Abstract: Background and Objective: Cadmium (Cd) is a non-essential metal whose dispersion in the environment has increased recently, Cd may enhance cell oxidative stress that leads to DNA damage and apoptotic cell death. The study aimed to evaluate the antioxidative capability of Burdock root ‘Arctium lappa’ on cadmium-induced oxidative stress and histopathology of the kidney of Wistar rats. Methodology: Cadmium was applied in a form of cadmium chloride to three groups (15 mg Cd kg–1) for five weeks with two groups pre-treated with ‘Arctium lappa’ administration, 100 and 200 mg kg–1 b.wt. Data were analyzed using one way analysis of variance (ANOVA) followed by Least Significant Difference (LSD) test to determine the difference among means using the JMP version 12. Results: Results revealed that cadmium induced a significant disorganization (p<0.05) of renal structure with collapsed tubular lamina and 76 μm tail length of the cells was observed, while histological sections of kidney pre-treated with 100 mg Arctium lappa kg–1 b.wt., showed a slightly less hypercellularity of glomerulus and reduction in the cell tail (59 μm). Furthermore, histological sections of kidney of rats pre-treated with 200 mg Arctium lappa kg–1 b.wt., showed high improvement of renal tubules and glomerulus with a prominent urinary space beside tail length of cells was recorded as 39 μm which was lower in comparison to other groups. Conclusion: Moreover, cadmium induced cellular destruction of the kidney was resumed with the pre-treatment of the secondary metabolites as an antioxidant compounds that produced from plant extracts. Arctium lappa leaf extract was efficient at both applied doses while 200 mg Arctium lappa kg–1 b.wt., had the most ameliorative effect.