Abstract: Leukocytosis and increased Erythrocyte Sedimentation Rate (ESR) during the early phases of acute ischemic stroke has been proposed to be related with poor prognosis. The aim of this study was to evaluate these two parameters in patients with ischemic stroke. In this descriptive analytical study, 150 patients with confirmed ischemic stroke were taken under study for a period of 13 month. The White Blood Cell (WBC) count and ESR were determined on admitting and after 3 days. Any history of Diabetes Mellitus (DM), Hypertension (HTN), Heart Disease (HD), Hyperlipidemia (HLP), smoking, CT scan findings, level of consciousness and the condition of patient on admission and discharge (according to Rankin's scale) were assessed. In this study, 150 patients were enrolled, in which 75 were males and 75 were females, with the mean age of 67.3±8.2 years. Leukocytosis on day one was significantly more prevalent in patients passed away during hospitalization or discharged in not-so-well condition. High WBC and ESR levels, altered consciousness, diffused lesions in CT scan and imperfect neurological condition on day one, as well as positive history of DM and HTN were significantly related with higher in-hospital death rate and/or poor condition at discharge. Raised WBC count and ESR just after an ischemic stroke attack might be related with a poor prognosis and necessitate immediate and meticulous monitoring and therapies.