Abstract: Chronic inflammation, as reflected by increased level of acute phase protein such as C-reactive Protein (CRP) is highly prevalent in hemodialysis patients. CRP is a strong predictor of overall and cardiovascular mortality and morbidity in hemodialysis patients. This research was conducted to determine the C-reactive Protein (CRP) levels and its correlation to demographic and clinical characteristics and Laboratory values in hemodialysis patients in Sari, Iran. In a cross sectional study, 147 hemodialysis patients were studied. Patients' demographic and clinical data were recorded and also serum CRP, Cholesterol, Albumin, Phosphorous, Calcium, Hemoglobin and Hematocrit levels were measured. Overall, the mean CRP concentration was 15.8 mg L-1. With considering to the different cutoff point (5, 6.2, 10 mg L-1) for CRP level, 107 patients (72.8%) had CRP level >5 mg L-1, 99 patients (67.3%) had CRP level>6.2 mg L-1 and 77 patients (52.4%) had CRP level >10 mg L-1. The CRP levels greater than 6.2, had a direct statistically significant correlation with duration of hemodialysis and phosphorus level (p = 0.01). Also, CRP levels above 10 mg L-1 had a direct statistically significant correlation with age and phosphorus levels (p = 0.02). According to the prevalence of high CRP level and it's correlation with age, duration of hemodialysis and phosphorus level in hemodialysis patients, CRP level should be screened in this group of patients routinely because of its prognostic importance.