Abstract: This present study was designed to determine the prevalence of H. pylori in infants and correlation of this infection with age. In a prospective descriptive study in Tabriz children hospital, we conducted analysis of children within age 2 year or younger who had H. pylori infection that were diagnosed with endoscopies and biopsy. Prevalence of infection was higher in the infants whose mothers had a low education level (p = 0.045). The H. pylori prevalence didn't differ between exclusively breastfeeding to six months and infants who had never breast fed (26.6% vs. 13.3%) (p = 0.2). We could not find any correlation between rate of infection and age of patients which used by regression model for analysis and t test (p = 0.5). Based on our study the prevalence of H. pylori infection in infants living in North West of Iran was low. We could not find any correlation between rate of infection and age of patients.