Abstract: The aim of this study was to evaluate characteristics of patients with pilomatricoma in Mazandaran Province, 1996-2006. In this study 46 case of pilomatricoma, with asymptomic, single and firm nodule referred to dermatology clinic of Boo-Ali Sina Hospital in Sari (1996-2006). A Biopsy was taken from suspicious lesions and histopathology assessments were done for cases with pilomatricoma impression. 69.56% patients were female. Mean age of the patients was 20.1 years .The most frequent sites of the tumor were the forearm (41.30%). It can be concluded, because the pilomatricoma is a benign cutaneous neoplasm with differentiation toward hair matrix, so that it is not seen in palm or plantar surface, but could present in any other area. Since, few of pilomatricoma lesions converted to malignant, so that it is better we resects total lesion by surgical excision.