Abstract: The study was planed to evaluate the effect of Echinacea (E.) on liver toxicity in rats treated with Cyproterone Acetate (CA). Rats were divided into 5 groups treated for 2 and 4 weeks, 1-control 2- Echinacea (63 mg/kg/day), 3-CA (25 mg/kg/day), 4-E.+CA and 5-E. for 1 week before E.+CA. All treatments were administered via an oral tube with the same mentioned doses. Rats treated with CA or E.+CA exhibited a significant increase in liver gamma glutamyl transpeptidase and malondialdhyde as compared with the control group. A marked decrease was recorded in all treated groups in comparison with the control with respect to glutathione peroxidase and superoxide dismutase. All treatments caused an increase in serum IGG and IGM in comparison with the control value. WBCs showed an increase after E. and CA treatment. While RBCs count and heamatocrit value showed a significant decrease in CA and E+CA treated rats in comparison with the control after four weeks of treatment. These data suggested that, E. possesses a protective effect on the liver against the CA toxicity by increasing auto immunity and blood picture components. Also the E. antioxidant properties exerted counteracting effects on the CA induced oxidative stress.