Abstract: Tea is one of the most popular beverages consumed worldwide. The relationship between tea consumption and human cancer incidence is an important concern. The effect of tea extract and ingredients, polyphenol and caffeine on the mutagenicity of Sodium Azide was examined in vitro by using Salmonella typhimurium TA100, TA98 and TA1535 in the presence of induced rat liver S9 fractions. Experimental studies have demonstrated the significant antimutagenic and anticarcinogenic effects of both Green and Black tea and its polyphenol and caffeine multiple mutational assay. Caffeine was the less active. Tea comes in many variants. Common tea such as Black tea contains little antioxidant and the amount of caffeine. Green tea has about the caffeine, but contains a good amount of antioxidant.