Abstract: The objectives of this study were to evaluate the effect of haemodialysis on plasma Cardiac Troponin I and cardiac enzymes before and after the dialysis process. Twenty two patients with Chronic Renal Failure (CRF) disease who were haemodialyzed at 5th Azar hospital of Gorgan Dialysis Center were recruited for this study (2005). The patients do not have coronary heart disease. Plasma cardiac enzymes showed no significant difference in the post dialysis group when compared with predialysis. Plasma levels of Cardiac Troponin I in 12 haemodialyzed patients were significantly increased in the postdialysis group when compared with predialysis, whereas plasma level of Cardiac Troponin I in 10 haemodialyzed patients were undetectable ( less than 0.1 μg L-1). The observation of meaningful increasing level of plasma Cardiac Troponin I in the haemodialyzed patients after the process of dialysis shows that Cardiac Troponin I is highly specific marker for Acute Myocardial Infarction (AMI) when compared with other cardiac enzymes and is particularly useful for detecting AMI in chronic renal failure and haemodialysis patients which can prevent sudden cardiovascular abnormality and sudden silent myocardial infarction in these patients.