Abstract: The pathology of experimental Trypanosoma evansi infection in Savannah Brown buck was studied using an isolate obtained from the blood of an infected camel slaughtered at Kano Abattoir, Nigeria. Gross pathological lesions observed included pale carcass with hydro peritoneum, generalized atrophy of the body fats, catarrhal enteritis, hepatomegally with bilaterally congested kidney, congested lungs with red hepatization of the liver. Histopathological lesions observed in the infected Savannah Brown buck included Zenkers necrosis of the myocardium with few mononuclear cellular infiltrations, focal areas and centrilobular necrosis of the liver, hemosiderin-laden macrophages involving the spleen and lymph nodes. There were degenerated seminiferous tubules and degenerated spermatids in the duct of the epididymis. The results of this study showed that the T. evansi isolate is pathogenic to the Savannah Brown buck.