Abstract: Coronary Artery Disease (CAD) is the leading cause of death in many populations, including Iranians. The best way to control CAD, is to identify and modify more effective local risk factors. The aim of this study was to determine and comparison of lipids, lipoproteins and lipoprotein (a) [Lp (a)] in patients with CAD who referred to cardiovascular research center. One hundred patients (37 females, 63 males) with CAD and 92 controls (58 females, 34 males) were investigated. The fasting plasma Total-cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), was determined by routine laboratory methods. Lp (a), apo-A1 and apo-B100 were determined by electroimmunoassay method. Statistical test included, t-test for comparison of lipids and U-test for comparison of Lp (a) in two groups. TC and Low-density Lipoprotein Cholesterol (LDL-C) in patients (227±35 and 147±40 mg dL-1, respectively) were higher than controls (208±54 and 127±39 mg dL-1). There were not any significant differences in TG, HDL-C and apo-A1 between two groups, but apo-B100 was higher in patients (1.25±0.4 g L-1) than controls (1.13±0.36 g L-1). Lp (a) was higher in patients (25±27 mg dL-1) than control (18.8±19.5), but was not statistically significant (p = 0.067). We concluded that high levels of cholesterol and cholesterol-rich lipoproteins are more associated with CAD. Lp (a) is more associated with CAD in women and TG is more effective risk factor for MI in our study population. These lipids and lipoproteins may be more effective local risk factor for incidence of CAD in some Iranian populations.