Abstract: Water deficit associate with salinity in irrigation water is the major limiting factor in the Center and East of Iran region. Nevertheless, an experiment was conducted in 2005 at Esfahan National Salinity Research. The purpose of this study was to evaluate effect of cropping methods and salinity stress on wheat agronomic characteristics. A Split plot layout within Randomized Complete Block Design with four replication were used. Irrigation quality water irrigation were in main plot, it consists in 4, 8 and 12 dS m-1 and cropping methods were in sub plots that inclusive of traditional cropping, 60 cm furrow, 80 cm furrow and aside sloping 80 cm furrow with double row planting. The results showed effect of raising salinity stress on 1000 grain weight, protein yield, grain yield, biological yield, straw yield and harvest index were decreased significantly. Effect of cropping methods on protein yield, biological yield and straw yield were more significantly. While, the highest amount of the traits agronomic were in 60 cm furrow cropping method, whereas the lowest the agronomic characteristics were in traditional cropping method with the exception of protein yield that lowest was in aside slopping 80 cm furrow. The effect of cropping methods on 1000 grain weight and harvest index were not significantly. According this study the suitable method with the highest traits agronomy in salinity stress was 80 cm method. While, the traditional cropping method did not recommended in high salinity stress condition.