Abstract: This study was carried out during 2000 and 2001 growing season in Sanliurfa province, Southeastern Anatolia Region of Turkey in order to determine yield, yield component and fiber technological traits of some cotton varieties. The experimental plots were arranged in a randomized complete block design with three replications. In the research, 15 cotton varieties were used to determine the higher yielding varieties. Seed cotton yields varied between 1884-4322 kg ha-1 in the research. In all the observed characters, statistically significant differences were determined among cultivars. As a result, Stoneville 453 was the highest yielding cultivar just ahead of Sayar-314 under irrigated conditions in Southeastern Anatolia Region.