Abstract: A pot experiment was conducted in a greenhouse as rainout shelter to investigate the response of diverse durum wheat cultivars under three levels of soil moisture. Four wheat cultivars namely Om-quais, Hourani-27, Safra Ma`an and Al-Samra were grown under three levels of soil moisture which are 50 (M1), 65 (M2) and 85% (M3) of field capacity. Results indicated that the cultivars were good drought tolerant because they were able to produce at M1 which is 4% below the wilting point. Cultivars didn`t differ significantly for yield and yield component, based on this similarity in response, cultivars can be alternatives to each other within the soil moisture levels. Soil moisture very significantly affected all characters, except harvest index, thus, increasing soil moisture levels from M1 to M2 and from M2 to M3 caused a great increase of 136 and 77% for biological yield/plant, 143 and 63% for grain yield/plant, 93 and 77% for straw yield/plant, 93 and 43% for number of spikes/plant, 137 and 44% for number of kernels/plant and by 7 and 10% for thousand kernels weight respectively. Under rainfed conditions, supplementary irrigation can improve wheat yield and avoid crop failure by limited amount of water.