Abstract: Dry seeds of common bean (Phaseolas vulgaris L. cv. Nebraska) were subjected to 0, 2 and 32 Krad of gamma rays from a cobalt-60 source and salt stress treatments (0, 1000, 2000 and 3000 ppm) of NaCl. The shoot length of the plants was significantly reduced only at the highest level (3000 ppm) of NaCl, while the root length was significantly inhibited by all NaCl levels. The contents of chlorophyll a and chlorophyll b did not change under all treatments, while carotenoids increased in response gamma irradiation in non-stressed plants. The high dose (32 Krad) of gamma irradiation caused incomplete inhibition of seedling growth which indicated 100% lethality. The low dose (2 Krad) significantly induced the shoot length, leaf area and pod fresh weight under salinity stress. In SDS-PAGE proteins, the total number of protein bands was reduced under all NaCl treatments. The synthesis of salt susceptible molecular weight polypeptides was completely inhibited at all levels of NaCl; while, the synthesis of the salt tolerant molecular weights was inhibited only at the highest level (3000 ppm) of NaCl. Responding against salinity stress, two new polypeptides were synthesized. The low dose (2 Krad) of gamma irradiation induced stability in the total number of protein bands and continuing synthesis of certain polypeptides under the highest level (3000 ppm) of NaCl. A synergistic interaction emerged between NaCl stress (3000 ppm) and nonlethal dose (2 Krad) of gamma irradiation resulted in salt tolerance in common bean (Phaseolas vulgaris L. cv. Nebraska) plants.