Abstract: Mesquit, Prosopis farcta (Banks and Sol.) Macbride, has become a serious weed problem in cultivated and non-cultivated areas in the Mediterranean and Southeast Anatolian Regions of Turkey. Caryedon palaestinicus Southgate (Coleoptera, Bruchidae; Pachymerinae), a seed feeding insect, has been determined in mesquit growing areas. In this study, C. palaestinicus infected seed rates of P. farcta were investigated. A thousand pods of P. farcta were collected separately from Antakya, Hassa and Kirikhan districts in 2000 and Altinozu, Kumlu and Reyhanli districts in 2001. Collected pods were placed individually: polyethylene bags and kept to the following July. Numbers of damaged seeds and healthy ones were recorded in July. Damaged seed rates for Antakya, Hassa and Kirikhan were 35.4, 34.9, 37.8%, respectively and for Altinozu, Kumlu and Reyhanli were 27.9, 37.2 and 38.0%, respectively. In addition Rhaconatus major Tobias (Hymoneptera, Braconidae) a larval parasitoid of C. palaestinicus was determined in the survey areas. It is concluded that C. palaestinicus was not a promising biological agent for controlling mesquit under field conditions.