Abstract: This study was carried out to examine the effects of intermittent hyperoxia and aging on the ultrastructure of hepatosyte, blood cholesterol and triglycerides levels in pigeon. Young and old pigeons were exposed to hyperoxia (100% O2), for 2 h daily for 6 weeks period. Ultrastructure of hepatocytes showed irregular clump of chromatin margination, large lipid accumulation, lipdec derbis and micropinocytosis vermiform. Baseline cholesterol of the young and the old groups were 288.30 and 441.83 mg/100 mL, respectively, which were significantly (p< 0.05) different. Following exposure to hyperoxia neither cholesterol for the young (288.30 vs 281.75 mg/100 mL) nor for the old (441.83 vs 443.37 mg/100 mL) changed significantly (p > 0.05) but the difference between the two groups remained significant (p<0.05). Thus hypercholesterolemia induced by aging remained independent of hyperoxia exposure. Baseline TG were 187.49 and 215.04 mg/100 mL for the young and old, respectively which were not significantly (p>0.05) different. Following exposure to hyperoxia TG decreased significantly (p<0.05) in the young group. Thus young pigeon were able to compensate for oxidized lipoprotein and the associated hepatocyte injury induced by oxidative stress.