Abstract: Fusarium moniliforme was able to grow in the presence of different concentrations of sodium tellurite (0.1-2.0) but at 3.0% (w/v) the fungus morphology was completely distorted. Growth of the fungus was decreased greatly by the increase of metals concentrations. Dark colour colony and black reverse were formed in the presence of tellurite. The fungal biomass was slightly stimulated. The presence of tellurium in the growth medium increased the cellular contents of carbohydrates, proteins and lipids. Moreover, the presence of tellurium induced the biosynthesis of several types of low molecular weight proteins. Total phospholipids were decreased with increasing tellurium concentrations.