Abstract: In this study, morphological, anatomical, properties and antimicrobial activities of Linaria corifolia Desf. which is an endemic plant of the Irano-Turanien phytogeographic region were investigated. Morphologically, it was observed that the species have a perennial root system, the herbaceous stem is cylindrical, erect and glaucous, leaves are filiform type. Inflorescence is many-flowered, bracts are linear-lanceolate, acute. Calyx lobes are lanceolate to oblong-ovate, Corolla pale lilac and spur narrowly conical. Stamens are didinam. Seeds are crescenti-trigonous, to tetrahedral, black. Anatomically, the internal morphological properties of root, stem and leaf were determined. It is observed that the extracts obtained from these plants have strong antimicrobial effect against the tested microorganisms used in this study.