Abstract: This study was carried out to analyse certain biochemical parameters altering in experimental anaphylaxis in goat. Goats were sensitized to horse serum and were subjected to systemic anaphylactic shock. Blood samples were collected at 24 h after each injection of antigen during sensitization and at 10, 60 and 240 min after antigenic challenge and analysed. Results revealed a significant increase in blood glucose during sensitization and post sensitization. Significant increase in serum sodium and potassium was observed at 10 min post antigenic challenge. Total serum lipids were significantly decreased during sensitization and after challenge. Serum total proteins were decreased significantly at the last injection of sensitization and 10 min after challenge. It is concluded that anaphylaxis induces blood biochemical changes in goats and suggested the development of disorders in cardiovascular and respiratory system in goat specie.