Abstract: The aim of this investigation was to evaluate the combination effects of germinated seeds of Trigonella foenum graecum (TFG) and Cholestyramine on blood lipids profile and fatty streak forming in rabbits. Twenty five male rabbits were divided into 5 groups and received the following diets and drugs for 45 days: Group I: normal diet, Group II: high cholesterol diet, Group III: High cholesterol in additional Cholestyramine (200 mg bid), Group IV: high cholesterol diet in additional to germinated seeds of TFG powder (600 mg bid) and Group V: high cholesterol diet in additional to Cholestyramine and TFG powder. Blood samples were collected after overnight fasting on the first and the last day of test period and estimated for lipid profile. Also autopsy and aortic cross-sectional sampling was done for microscopic study after experiment. The serum cholesterol total, LDL and triglyceride levels of Group III, IV, and V were significantly increased less than levels of Group II but HDL level in Group III, IV and V increased more than Group II. The intensity of fatty streak was less in Group V. These results indicate the usefulness of combination of TFG and Cholestyramine in management of hyperlipidemia and atherosclerosis.