Abstract: The measured mean activities of 226Ra, 232Th, 40K and 137Cs in the soil of Bahawalpur, Bahawalnagar and Rahimyar Khan Districts were 32.9, 53.6, 647.4 and 1.8 Bq kg-1. The average absorbed dose rate calculated from these activities was 62.1n Gy h-1 and the annual equivalent dose rate was found to be 0.5 m Sv y-1. Effective doses to different body organs were derived from annual equivalent doses with the help of tissue weighting factors. Fatal cancer risks were assessed by using ICRP 60 Model. Estimations incurred 309 deaths per year due to cancer.