Abstract: The activities of two flavanoids, liquiritigenin and isoliquiritigenin, from Amboyna wood against the pathogenic fungi Corynespora cassiicola, Trichoderma harzianum, Fusarium oxysporum, Cochliobolus miyabeanus, Aspergillus niger and Penicillium italicum were evaluated using the agar dilution and paper disk methods. Low concentrations of liquiritigenin (20-40 μM) and isoliquiritigenin (16-33 μM) satisfactorily inhibited the growth of all the test fungi. Antifungal activities of the two flavonoids were found to be concentration-dependent. This is the first report that flavonoids from Amboyna wood are active against fungi pathogenic to the plants.