Abstract: Repeated plasma transfusion was performed in 12 indigenous Bangladeshi calves (age: 6-10 months, weight: 35-45 kg) to study its effects on various hematological and clinical parameters and to observe the incompatible reactions associated with plasma transfusion. The pre-transfusion values of Total Erythrocyte Count (TEC), Hemoglobin (Hb) and Packed Cell Volume (PCV) decreased 1 h after transfusion and thereafter started increasing from day-1 and a significant increase (p<0.05) was observed at day-3. The Total Serum Protein (TSP) increased 1 h after transfusion and a significant increase (p<0.05) was noticed from day-1. The pattern of changes in the hematological parameters in the recipient calves was similar in first and second transfusions. No significant changes were observed in the heart rate, respiration rate and rectal temperature. Plasma transfusion appeared to improve the hematological parameters and repeated transfusions did not produce any adverse reaction in the recipient calves. Plasma transfusion could be an effective tool for the management of anemic and emaciated calves.