Abstract: The root of Cassia tora exhibited substantial antishigellosis activity. The ethylacetate fraction of the crude extract showed maximum activity with the zone of inhibition ranging between 23-25 mm at the concentration of 200 μg disc-1. The minimum inhibitory concentration (MIC) of ethylacetate, chloroform and ethanol extracts was found between 32-64 μg ml-1 whereas the methanol and petroleum fractions showed MIC values between 128-512 μg ml-1. Thus the results suggest that the ethylacetate fraction may have some chemical constituents which could be useful as antishigellosis agents in modern clinical practice. Our effort is going on to isolate the potent antishigellosis constituents from the root extracts of Cassia tora with the aim of adding new therapeutic agents to fight against shigellosis problem in Bangladesh