Abstract: Apparent Digestibility Coefficients (ADC) of protein in anchovy (Engraulis encrasicolus), corn (Zea mays) gluten, soybean (Glycine hispida), gammarid (Gammarus kischineffensis) and crayfish (Astacus leptodactylus leptodactylus) exoskeleton meals was determined for juvenile Nile tilapia, Oreochromis niloticus. In each of five trials, a reference diet was mixed with test ingredients in a 70:30 ratio to produce a series of test diets. Chromic oxide was added as a marker to the reference diet. The ADC for protein were; anchovy (90.2%), corn gluten (88.5%), soybean (87.6%), gammarid (76.3%) and crayfish exoskeleton (70.9%) meals (p<0.05 for each case, except for anchovy, corn gluten and soybean meals). The results of the study indicated that O. niloticus may efficiently utilise gammarid and crayfish exoskeleton meals as dietary protein source, like anchovy, corn gluten and soybean meals.