Abstract: Methanolic leaf extract of Adansonia digitata was administered intragastrically to normal and alcohol fed rats to determine the effects of the extract on serum electrolytes and some Biochemical parameters. The leaf extract was administered for two weeks at a dose of 0.75 g kg-1 body weight. The parameters studied were the major electrolytes (Na+, K+, Cl- and HCO3-), glucose, albumin and total protein. Results obtained shows that the leaf extract has no significant effect on these parameters (P<0.05), except albumin. The serum albumin level of normal rats decreased to 29.3±0.72 g L-1 from 33.8±0.52 g L-1 when fed with the extract. This effect may result from the reduction in or inhibition of albumin synthesis by the liver. The serum albumin level on administration of the extract to the alcohol fed rats was also significantly reduced; from 29±0.56 to 26.8±0.52 g L-1 (P<0.05). The hypoalbuminemia that results on the administration of this extract may be due to the possible action of Adansonia digitata on liver function that consequently affects the production of albumin. Physiological effects of this are decreases in osmotic pressure and in transportation of some organic molecules carried by albumin. No significant effect is observed in the level of total protein.