Abstract: In the present study 1694 cases of typhoid in Sokoto of Northern Nigeria, were analyzed based on the examination of monthly medical record at the Usmanu DanFodiyo University Teaching Hospital. The result shows that 531 (31.4%) of the patients were admitted (in patients) while 1162 (68.6%) of the patients were treated for typhoid at the out patient department of the hospital during the study period. Of those admitted, more males (313 or 58.9%) than females (218 or 41.1%) were affected, but sex-related difference in infection rates did not vary significantly (P>0.05). The fatality rate (1.5%) was due mainly to intestinal perforation (3.4%) and meningitis (1.2%). Young adults of 11-20 years and adolescents of 21-30 years age grades were the most vulnerable members of the community and disease prevalence rates among them were 36.5 and 31.6%, respectively. Computed F-statistic suggested that there was a uniform yearly increase (P< 0.05) in number of cases and this was probably due to improved diagnosis and increased awareness, which enhanced case presentations at the hospital. In a follow-up study, an unstructured interview and questionnaire survey among health workers in local health institutions indicated that the predisposing factors for typhoid in study area were related mainly to personal, food, drinking-water and environmental hygiene and these persisted throughout the months of the study years.