Abstract: A Study was conducted on the salt stress culture of blue green algae S. fusiformis. The blue green algae S. fusiformis was grown at the different salinity of sea water as 0.2, 0.5, 1.0, 1.2, 1.5, 3.0, 5.0, 7.0, 14.0, 15.0, 16.0, 17.0 and 18.0 ppt which were enriched with Zarouk medium. A new steady state was established after carry out an initial lag phase. The observed growth rate was slower and inversely related with concentration of salt stress i.e. the more was salinity, the slower was growth rate during the experiment. Instead of growth, a decrease in biomass was also observed in high salinity. The specific growth rate at all salt stress culture was lower than that of control (0 ppt). The result showed that the protein and carbohydrate content were varied from 37.3 to 56.1% and 16.8 to 31.4 %, respectively. At 1.0 and 1.2 ppt a marked increase in lipids of 19.6 and 15.6% were observed. Highest carotenoid content of 3.53 mg-1 g dry weight was found at 16 ppt, which is significantly (P<0.05) higher compared to control. Phycocyanin was high at 1 ppt (93 mg 1 g dry weight), which is significantly lower than that of control. The result showed that the production of lipids and carotenes in salt stress culture which would be 1-1.2 ppt and 15-16, ppt respectively in laboratory culture conditions.