Abstract: The low levels of T4 (thyroxine) and T3 (triiodothyronine) can be observed in the dogs with hypothyroidism, but it could also reflect some other illness, in which the function of the thyroid gland is not disturbed. This phenomenon is called "sick euthyroid syndrom" (SES) and it is mainly associated with the existence of the other endocrinopathies (Cushing`s syndrome, hyperestrogenism). The other endocrinopathies could be clinically manifest by very similar chronic changes in the skin and hair as those manifested in hypothyroidism. There are two cases of German shepherd dogs which were manifested by obesity, lethargy, infertility and chronic dermal findings. The level of T4 in the blood serum was very low in the first bitch T4 = 4.53 n mol l-1 and in the second bitch T4 = 12.84 n mol l-1. Diagnostic biochemical blood examination revealed results indicating the possibility of hypothyroidism, but at the same time also the possibility of another non- thyroid disease. Homeopathy can help to solve the problem of theraphy in such complicated cases. After homeopathic therapy the results of the biochemical and endocrinological examinations repeatedly showed the restored conditions of the patient. The level of the T4 in the blood serum was in the first bitch T4 = 27.31 n mol l-1 and in the second bitch T4 = 26.28 n mol l-1. This study presents the possibility to use homeopathic treatment in chronic dermatologic cases.