Abstract: Diabetes mellitus and hypertension frequently coexist. A variety of aberrations have been reported in the metabolism of body chief electrolytes (such as Na+, K+, Ca++ and Mg++) and their transport systems in intra and extracellular environment in various metabolic disorders. The study was aimed to examine the similar abnormality in diabetes with hypertension. Thirty hypertensive diabetic patients were selected verses same number of age and sex matched controls with no known history of hyperglycemia and hypertension. A significant difference was observed in blood pressures of both the groups. Intra-erythrocyte sodium level was observed elevated significantly (P<0.01) where as intra-erythrocyte potassium was observed lower significantly (P<0.05) in hypertensive diabetic patients. The serum sodium, calcium, magnesium as well as membrane Na-K-ATPase activity were observed reduced to a significant level (P<0.01) where as serum potassium level was also found reduced significantly (P<0.05) in hypertensive diabetic patients as compare to controls. These findings suggest that the constellation of disturbed cellular ions and their transport mechanisms may critically contribute to pathophysiology of these syndromes and may help to explain their frequent clinical coexistence.