Abstract: Prolifertive kidney disease was investigated at a Romsey fish farm on the River Test, Hampshire, U.K. A total of 200 fish of age 0+were collected from one selected tank between August and September 1987. The degree of PKD infection was classified low, medium and high. Regression analysis showed significant difference between PKD infected and uninfected fish. Logistic regression indicated that PKD had significant relationship with both (-ve) time and (+ve) temperature. Chloramine-T and Oxolinic acid were used as a chemical management.