Abstract: The present study was carried out to assess the lipid profile in relation to sex, age in non-obese and non-diabetic patients with essential hypertension among human population of Multan, Pakistan for a period of 24 months from June 2001 to May 2003. The study revealed that there was a highly significant effect of age on total cholesterol of both hypertensive and normotensive individuals.The highest level of total cholesterol was present in hypertensive patients of 41-45 age group. The normotensive had low level of total cholesterol than hypertensive. There was no effect of age on triglycerides and HDL cholesterol. Hypertensive patients had higher level of LDL cholesterol than normotensive. The male had significantly higher level of total cholesterol than female and higher LDL cholesterol. The male had marginally higher level of triglycerides than females. There was no effect of sex on HDL cholesterol. When comparison was made between mild, moderate and severe hypertensive patients, it was found that severe hypertensive patients had significantly higher level of total cholesterol and triglycerides than mild and moderate hypertensive patients. There was no effect of severity of hypertension on HDL cholesterol and LDL cholesterol.