Abstract: The effect of aqueous leaves extract of M. balsamina on acetic acid induced writhes/stretches (Anti nociceptive/analgesic effect) and egg albumen induced edema (Anti-inflammatory effect) was studied. Three different doses of the leaves extract were administered to three groups of rats 30 minutes prior to the administration of acetic acid. Pentzocin was used as the standard Analgesic drug. Another Randomized Block Design of three blocks was administered with three different doses of the leaf preparation 30 minutes prior to the induction and oedema with egg alburnen. Pure aspirin was used as the standard anti-inflammatory agent. The treatment with the plant preparation cause dose dependent significant (p<0.05) protection against the writhes/stretches produced by acetic acid administrations and oedema induced by egg albumen. These protections were found to be superior to those of the standard drugs used. The result of the findings establishes the analgesic and anti-inflammatory effect of the aqueous extract of M. balsamina and concludes therefore, that there was a positive correlation (r = 90) in the dose response relationship for both analgesic and anti-inflammatory effect.