Abstract: Urinary excretion of acetylsalicylic acid (aspirin) as free Salicylic Acid (SA) was observed in 12 healthy young female volunteers. After oral administration of 600 mg of drug (ASA) urine samples were collected at predetermined time intervals. Mean±SE value for pH of urine in this study was 6.04±0.14, diuresis was 0.029±0.005 mLmin1 kg1, concentration of free Salicylic Acid (SA) was 44.66±0.389 μg mL1. Mean ±SE value for rate of excretion was 1.087±0.247 μg min1 kg1, amount excreted was 6.445±1.188 mg and percentage dose excreted was 1.076±0.197 percent. The mean ±SE value for the cumulative amount excreted was 20.85±2.708 mg and percent cumulative amount excreted was 6.45±0.64 percent. The results indicated that there was low urinary excretion under indigenous conditions.