Abstract: Lead and nickel toxicity in the body organs of fish viz. Catla catla, Labeo rohita and Cirrhina mrigala and water was studied in the stretch of river Ravi from Baloki headworks to Sidhnai barrage. Significant variations were recorded in water samples and four fish organs for the concentration of metals. Lead accumulation was higher in fish gills and liver than in kidney and muscle. Nickel concentration was the maximum in liver followed by that in kidney, gills and muscle. Metal concentrations in water were significantly correlated with the temperature. However, lead in water showed positively non-significant regression on water pH. The accumulation of nickel in three fish species did not vary significantly. However, Catla catla, showed non-significantly higher tendency to concentrate lead in its body than Labeo rohita.