Abstract: The effect of some wheat genotype grains inoculated with Azosperillum brasilense and Azorhizobium caulinodanse on wheat yield and NPK uptake was evaluated under different levels of liquid N-fertilization (0, 50 and 100% from the recommended N Kg/fed). Inoculation with any biofertilizer leads to considerable improvement in wheat grain and straw yield as compared with their respective control. However response differed according to the type of boifertilizers. The superiority related to Azorhizobium inoculation was clear on grain yield followed by inoculum containing a mixture of Azorhizobium and Azosperillum, although the use of Azosperillum gave the lowest response, but it was still higher than the uninoculated plants (control). Increasing levels of nitrogen caused increase in the wheat grain and straw yields, but the response was remarkably high at 100% N. The differences in grain yield became much lower when Azosperillum in combination with decreasing levels of N-fertilizer were used. The relative increase was 4.8% (when Azorhizobium + 100% N were used. At the same time the application of 100% N exceeded using both 100% N + Azosperillum (13.3%) and 100% N + mixture of inoculation (12.54%). Application of 100% N mixed with Azorhizobium + Azosperillum inoculum gave a positive effect and also affected the 1000-grains weight. This response varied according to the wheat varieties especially with Sakha 8 which gave the highest response. Differences in NPK uptake depend on wheat genotype and on different microbial treatments. The application of Azorhizobium +100% N enhanced the mineral uptake followed by mixture of 100% N + (Azosperillum + Azorhizobium) inoculums.