Abstract: The effect of cisplatin (8 mg/kg b.wt. i.p) on the haemopoietic system alone or in combination with lasix (0.25 mg/kg b. wt, i.m) or sodium selenite (20 μ mol/kg b. wt. i.m) or both were discussed in the male albino rabbits for 6 weeks. The IP injection of cisplatin induced a marked decreases in body weight, in the number of red blood cells; haemoglobin contents; haematocrit values and iron levels in the plasma, accompained by an elevations in total bilirubin. Co-administration of lasix with cisplatin partially improved the loss of body weight and the treatment of haematological parameters. Co-administration of selenium with cisplatin partially improved the loss of body weight and completely improved the haematological parameters. Treatment of cisplatin with lasix or sodium selenite or both completely prevented haematological toxicity of cisplatin and the animals restored their normal weight.