Abstract: The antinociceptive activities of several extracts (water, phosphate buffer solution, ethanol and methanol) of sea cucumber Stichopus chloronotus Brandt were evaluated in mice using the abdominal constriction and hot tail-flick test in comparison to morphine and normal saline being positive and negative control, respectively. The control group exhibited no significant effect whereas morphine sulphate (0.8 mg/kg) and all the extracts at various doses (10, 30, 50 mg/kg) reduced acetic acid-induced abdominal constriction.