Abstract: The pleurisy model in rats was used to study the pharmacology of extracts from the sea-cucumber Stichopus badionotus Selenka. Ten control animals were injected intrapleurally with 0.1ml carageenan (1%) and their pleural cavities were examined. Three groups (six animals per group) were treated with concentrations of 5, 10 and 20 mg/ml of the ethanol extract of sea-cucumber given i.p. and three other groups were treated with similar concentrations of a phosphate-buffer extract also given i.p. A half-hour later the animals were administered carageenan (i.p.). These animals were killed four-hours after the administration of carageenan and their pleural cavities were examined. The results showed that the extracts were able to reduce pleural effusion, neutrophil counts, and also adenosine deaminase activity significantly and in a dose-dependent manner. The effects were more pronounced with ethanol extract compared to the phosphate-buffer extract.