Abstract: The treatments comprised of four sizes of seedling tubers viz. 5.0, 7.5, 12.5 and 17.5 g derived from the TPS progeny HPS II/67 and four depths of planting viz. surface level, 2.5, 5.0 and 7.5 cm with their all possible combinations. Seedling tuber size significantly influenced the growth and yield of potato. Yield was found to increase with the increase in seedling tuber size and the maximum yield (39.34 t/ha) was obtained from the large seeds (17.5g). Depth of planting had no significant effect on the growth and yield of potato. The combined effect of seedling tuber size and planting depth revealed that the maximum yield per hectare (39.42 t/ha) was obtained from the large seedling tuber (17.5 g) with the planting depth of 5.0 cm. Economic analysis indicated that the best economic return was obtained from 17.5 g seedling tubers planted at a depth of 7.5 cm.