Abstract: Imazethapyr herbicide (pursuit*) singly or combined with urea fertilizer on mitotic activity, inducation of mitotic and meiotic abnormalities and changes in the M2 seed storage protein banding patterns has been investigated on Vicia faba plants. A significant reduction in mitotic index was induced after different treatment in both forms (singly or combined). A variety of chromosomal abnormalities were observed in both mitotic and meiotic divisions respresented by stickiness, disturbance, laggards, bridges, multipolar, C-metaphase, breaks and micro and multinuclei. The frequency of these types of abnormalities decrease in case of pursuit herbicide combined with urea fertilizer. Electrophoretic analysis showed that pursuit and its combination with urea has a great ability to induce changes in the protein banding patterns of Vida faba seed storage protein as compared with untreated samples being more pronounced in treatment with the herbicide singly.