Abstract: Extracts of Launaea nudicaulis and L. resedifolia were subjected to the demonstration of insecticidal and cytotoxic activities by standard methods; the former was measured against red flour beetle and Sabz Tela and the later by brine-shrimp assay. Methanolic extracts of L. nudicaulis and L. resedifolia at concentration of 0.786 mg/cm2 exhibited 27.5±5 and 45±11 percent insecticidal activity against red flour beetle. L. nudicaulis was also insecticidal against Sabz Tela of cotton plant upto 100% activity. When the cytotoxicity was measured, alcoholic as well as aqueous extracts of both these plants killed larvae at 1mg/ml concentration upto 60-100 percent.