Abstract: The investigation of the effects of intravenous (i.v.) infusion of α2-adrenoreceptor agonists and antagonists on reticuloruminal motility was carried out in conscious goats. The i.v. administration of the α1-agonist phenylephrine (4 μg kg–1 min–1 for 15 min) or the α2-agonist naphazoline (2.5 μg kg–1 min–1 for 15 min) reduced both frequency and amplitude of reticulum and rumen dorsal sac contractions. Pretreatment of animals with the α1-antagonist prazosin (20 μg kg–1 min–1 for 30 min) prevented the inhibitory effects of phenylephrine on reticuloruminal motility. The effects of naphazoline were prevented by yohimbine, an α2-antagonist at 20 μg kg–1 min–1 for 30 min. Yohimbine, given alone or followed by naphazoline, abolished secondary ruminal dorsal sac contractions. It is concluded that both α12 and α2-adrenoreceptors are involved in the regulation of reticuloruminal motility in the goat. At the dosage of drugs used al and α2-adrenoreceptors appear to play an inhibitory effect on reticuloruminal motility in the goat.